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Article

MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens.

Genome biology - 1 Jan 2014

Li Wei, Xu Han, Xiao Tengfei, Cong Le, Love Michael I, Zhang Feng, Irizarry Rafael A, Liu Jun S, Brown Myles, Liu X Shirley

Abstract excerpt

We propose the Model-based Analysis of Genome-wide CRISPR/Cas9 Knockout (MAGeCK) method for prioritizing single-guide RNAs, genes and pathways in genome-scale CRISPR/Cas9 knockout screens. MAGeCK demonstrates better performance compared with existing methods, identifies both positively and negatively selected genes simultaneously, and reports robust results across different experimental conditions. Using public...

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Source

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Identifiers

PMID: 25476604
DOI: 10.1186/s13059-014-0554-4
PMCID: PMC4290824

Genes

BCR
ABL1
BRAF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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