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Article

Human gene essentiality.

Nature reviews. Genetics - 1 Jan 2018

Bartha István, di Iulio Julia, Venter J Craig, Telenti Amalio

Abstract excerpt

A gene can be defined as essential when loss of its function compromises viability of the individual (for example, embryonic lethality) or results in profound loss of fitness. At the population level, identification of essential genes is accomplished by observing intolerance to loss-of-function variants. Several computational methods are available to score gene essentiality, and recent progress has been made in...

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PMID: 29082913
DOI: 10.1038/nrg.2017.75

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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