Article

Mapping the genomic landscape of multidrug resistance in <i>Plasmodium falciparum</i> and its impact on parasite fitness

2023-06-03

Abstract excerpt

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian KEL1/PLA1 lineage. We mapped k13 as the central mediator of ART resistance and identified secondary markers. Appl...

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Literature Corpus work: 9bf1d09a-f9df-5042-98b8-73910ac5a3e6
DOI: 10.1101/2023.06.02.543338

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