Article
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria.
Nature - 30 Apr 2015
Mbengue Alassane, Bhattacharjee Souvik, Pandharkar Trupti, Liu Haining, Estiu Guillermina, Stahelin Robert V, Rizk Shahir S, Njimoh Dieudonne L, Ryan Yana, Chotivanich Kesinee, Nguon Chea, Ghorbal Mehdi, Lopez-Rubio Jose-Juan, Pfrender Michael, Emrich Scott, Mohandas Narla, Dondorp Arjen M, Wiest Olaf, Haldar Kasturi
Abstract excerpt
Artemisinins are the cornerstone of anti-malarial drugs. Emergence and spread of resistance to them raises risk of wiping out recent gains achieved in reducing worldwide malaria burden and threatens future malaria control and elimination on a global level. Genome-wide association studies (GWAS) have revealed parasite genetic loci associated with artemisinin resistance. However, there is no consensus on...
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