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Genetic mapping of fitness determinants across the malaria parasite <i>Plasmodium falciparum</i> life cycle

2019-03-06

Abstract excerpt

Malaria is transmitted through female Anopheline mosquitoes where gamete fusion and meiosis occurs, and humans where parasites proliferate asexually. We describe a powerful approach to identify the genetic determinants of parasite fitness across both invertebrate and vertebrate life-cycle stages in human malaria parasite Plasmodium falciparum using bulk segregant analysis (BSA). We combined experimental genetic c...

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Literature Corpus work
da5bf48c-0d0a-598b-9a0b-fe64b60fab96
DOI
10.1101/570085
Open publication

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Genetic mapping of fitness determinants across the malaria parasite <i>Plasmodium falciparum</i> life cycleDOI 10.1101/570085
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