The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

doi:10.1038/s42003-021-02210-1

Article

The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice

14 Jun 2021

Abstract excerpt

Genetic crosses are most powerful for linkage analysis when progeny numbers are high, parental alleles segregate evenly and numbers of inbred progeny are minimized. We previously developed a novel genetic crossing platform for the human malaria parasite Plasmodium falciparum, an obligately sexual, hermaphroditic protozoan, using mice carrying human hepatocytes (the human liver-chimeric FRG NOD huHep mouse) as the...

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