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Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

14 Oct 2019

Abstract excerpt

Determining the genetic basis of fitness is central to understanding evolution and transmission of microbial pathogens. In human malaria parasites (Plasmodium falciparum), most experimental work on fitness has focused on asexual blood stage parasites, because this stage can be easily cultured, although the transmission of malaria requires both female Anopheles mosquitoes and vertebrate hosts. We explore a...

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PMID: 31609965
DOI: 10.1371/journal.pgen.1008453

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