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<i>Plasmodium falciparum</i> quinine resistance is multifactorial and includes a role for the drug/metabolite transporters PfCRT and DMT1

2024-09-28

Abstract excerpt

The genetic basis of Plasmodium falciparum resistance to quinine (QN), a drug used to treat severe malaria, has long been enigmatic. To gain further insight, we used FRG-NOD human liver-chimeric mice to conduct a P. falciparum genetic cross between QN-resistant (Cam3.II) and QN-sensitive (NF54) parasites, which also differ in their susceptibility to chloroquine (CQ). By applying different selective conditions to p...

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Identifiers and source

Literature Corpus work
e7a8afa9-9be4-5ac3-9b74-85be6c3f3244
DOI
10.1101/2024.09.27.615529
Open publication

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