Article

Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice

2021-11-24

Abstract excerpt

<h4>Background: </h4> Classical genetic crosses in malaria parasites involve isolation, genotyping, and phenotyping of multiple progeny parasites, which is time consuming and laborious. Bulk segregant analysis (BSA) offers a powerful and efficient alternative to identify loci underlying complex traits in the human malaria parasite, Plasmodium falciparum. <h4>Methods:</h4> We have used BSA, which combines genetic c...

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Literature Corpus work: 80f39348-f022-558e-8f5d-beebd74f9634
DOI: 10.1101/2021.11.24.469878

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