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A <i>Plasmodium falciparum</i> PX1 haplotype is associated with reduced susceptibility to artemisinin and lumefantrine

2026-05-11

Abstract excerpt

Effective control of falciparum malaria depends on the sustained efficacy of frontline antimalarial drugs, particularly artemether-lumefantrine (AL), the most widely used therapy in Africa. However, the emergence of artemisinin partial resistance and reduced lumefantrine susceptibility in eastern Africa threaten malaria control and elimination. Robust genetic markers of decreased susceptibility to lumefantrine rem...

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Literature Corpus work
e0422301-5b64-51b7-b40e-da9fed36af49
DOI
10.64898/2026.05.05.722990
Open publication

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