Article
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
Science (New York, N.Y.) - 5 Aug 2011
Yuan Jing, Cheng Ken Chih-Chien, Johnson Ronald L, Huang Ruili, Pattaradilokrat Sittiporn, Liu Anna, Guha Rajarshi, Fidock David A, Inglese James, Wellems Thomas E, Austin Christopher P, Su Xin-zhuan
Abstract excerpt
Malaria remains a devastating disease largely because of widespread drug resistance. New drugs and a better understanding of the mechanisms of drug action and resistance are essential for fulfilling the promise of eradicating malaria. Using high-throughput chemical screening and genome-wide association analysis, we identified 32 highly active compounds and genetic loci associated with differential chemical...
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