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Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing.

Antimicrobial agents and chemotherapy - 18 Jan 2022

Kanai Mariko, Yeo Tomas, Asua Victor, Rosenthal Philip J, Fidock David A, Mok Sachel

Abstract excerpt

Research efforts to combat antimalarial drug resistance rely on quick, robust, and sensitive methods to genetically characterize Plasmodium falciparum parasites. We developed a single-nucleotide polymorphism (SNP)-based genotyping method that can assess 33 drug resistance-conferring SNPs in dhfr, dhps, pfmdr1, pfcrt, and k13 in nine PCRs, performed directly from P. falciparum cultures or infected blood. We also...

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Identifiers

PMID: 34694871
DOI: 10.1128/AAC.01163-21
PMCID: PMC8765236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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