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Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

8 Nov 2023

Abstract excerpt

Drug-resistant Plasmodium falciparum parasites have swept across Southeast Asia and now threaten Africa. By implementing a P. falciparum genetic cross using humanized mice, we report the identification of key determinants of resistance to artemisinin (ART) and piperaquine (PPQ) in the dominant Asian KEL1/PLA1 lineage. We mapped k13 as the central mediator of ART resistance in vitro and identified secondary...

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PMID: 37939186
DOI: 10.1126/sciadv.adi2364

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