Article

Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury

2023-08-04

Abstract excerpt

<title>Abstract</title> Apolipoprotein-E4 (ApoE4), the strongest genetic risk factor for sporadic Alzheimer’s disease, is also a risk factor for microvascular pathologies leading to cognitive impairment, particularly subcortical white matter injury. These effects have been attributed to alterations in the regulation of the brain blood supply, but the cellular source of ApoE4 and the underlying mechanisms remai...

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Literature Corpus work: 9bc7927b-8053-5e07-99b8-689b80d72100
DOI: 10.21203/rs.3.rs-3222611/v1

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