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Article

The role of APOE in cerebrovascular dysfunction.

Acta neuropathologica - 1 May 2016

Tai Leon M, Thomas Riya, Marottoli Felecia M, Koster Kevin P, Kanekiyo Takahisa, Morris Alan W J, Bu Guojun

Abstract excerpt

The ε4 allele of the apolipoprotein E gene (APOE4) is associated with cognitive decline during aging, is the greatest genetic risk factor for Alzheimer's disease and has links to other neurodegenerative conditions that affect cognition. Increasing evidence indicates that APOE genotypes differentially modulate the function of the cerebrovasculature (CV), with apoE and its receptors expressed by different cell...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26884068
DOI: 10.1007/s00401-016-1547-z
PMCID: PMC4837016

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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