Article

Functional border-associated macrophages limit Alzheimer’s Disease progression

2026-02-03

Abstract excerpt

Brain-resident macrophages are known to play numerous roles in the progression of Alzheimer’s Disease (AD). However, the relative contribution of microglia and border-associated macrophages (BAM) to AD pathogenesis has been difficult to disentangle. We recently identified Maf , a newly described AD GWAS gene, as essential for BAM, but not microglial, survival. By crossing BAM depleted mice with the 5xFAD AD model...

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Literature Corpus work: a3621dbd-abac-5cb7-9ba2-6a0b5d8187c5
DOI: 10.64898/2026.01.31.703045

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