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Article

Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease.

Nature communications - 7 Jun 2021

Fitz Nicholas F, Nam Kyong Nyon, Wolfe Cody M, Letronne Florent, Playso Brittany E, Iordanova Bistra E, Kozai Takashi D Y, Biedrzycki Richard J, Kagan Valerian E, Tyurina Yulia Y, Han Xianlin, Lefterov Iliya, Koldamova Radosveta

Abstract excerpt

APOE and Trem2 are major genetic risk factors for Alzheimer's disease (AD), but how they affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific phospholipid signature with correlation between human APOEε3/3 and APOEε4/4 AD brain and lipoproteins from astrocyte conditioned media of APOE3 and APOE4 mice. Using preclinical AD mouse models, we show that APOE3 lipoproteins, unlike...

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Amyloid beta-Protein Precursor
Apolipoprotein E3
Apolipoprotein E4
Microglia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Immunologic

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Identifiers

PMID: 34099706
DOI: 10.1038/s41467-021-23762-0
PMCID: PMC8184801

Genes

APOE
TREM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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