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Article

APOE genotype-specific differences in human and mouse macrophage nitric oxide production.

Journal of neuroimmunology - 1 Feb 2004

Colton Carol A, Needham Leila K, Brown Candice, Cook Danielle, Rasheed Karima, Burke James R, Strittmatter Warren J, Schmechel Donald E, Vitek Michael P

Abstract excerpt

Individuals expressing an APOE4 genotype demonstrate increased Alzheimer's disease (AD) neuropathology and a decreased onset age. The APOE4 gene may act by modulating the CNS immune response. Using human monocyte-derived macrophages (MDM), we show a significantly greater increase in NO production during immune activation in MDM from APOE4 AD patients compared to normal, age-matched individuals or to AD patients...

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Source

Identifiers

PMID: 14741429
DOI: 10.1016/j.jneuroim.2003.10.015

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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