Article

Inheritance of OCT4 predetermines fate choice in human embryonic stem cells

2017-05-12

Abstract excerpt

Clonal cells can make different fate decisions, but it is often unclear to what extent these decisions are autonomous or predetermined. Here, we introduce a live-cell reporter for the pluripotency factor OCT4 into human embryonic stem cells to understand how they choose between self-renewal and differentiation. By tracing the histories of individual cells over multiple generations, we found that cells whose offspr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9b581637-15fc-5abd-ade4-8586509f6a4d
DOI: 10.1101/137299

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Inheritance of OCT4 predetermines fate choice in human embryonic stem cellsDOI 10.1101/137299Read

Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.Semantic proximity Read

Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal.Semantic proximity Read

Genetic exploration of the exit from self-renewal using haploid embryonic stem cells.Semantic proximity Read

Single-cell dynamics of core pluripotency factors in human pluripotent stem cellsSemantic proximity Read

Wnt/β-catenin signaling promotes differentiation, not self-renewal, of human embryonic stem cells and is repressed by Oct4Semantic proximity Read

A transcriptional clock of the human pluripotency transitionSemantic proximity Read

Generation and Trapping of a Mesoderm Biased State of Human PluripotencySemantic proximity Read

WT1 splice isoforms configure lineage bias during formative pluripotencySemantic proximity Read

Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-Differentiation with iPSC Reprogramming FactorsSemantic proximity Read

High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias.Semantic proximity Read

The Regulation of Self-Renewal in Human Embryonic Stem CellsSemantic proximity Read

Efficient Reprogramming of the Epiblast Enables the Generation of Cloned MiceSemantic proximity Read