Article

Single-cell dynamics of core pluripotency factors in human pluripotent stem cells

2022-12-14

Abstract excerpt

<h4>Summary</h4> The human transcription factors OCT4, SOX2, and NANOG form a core signaling network critical for maintaining stem cell pluripotency and self-renewal potential. The spatiotemporal expression dynamics of these pluripotency factors throughout differentiation is unclear, limiting our understanding of stem cell fate decisions. Here, we combined CRISPR/Cas9-mediated gene editing with microraft array te...

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Literature Corpus work: 7d3d5a85-6c5f-5cc2-981f-f80c2e88932a
DOI: 10.1101/2022.12.13.520282

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