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Article

Genetic exploration of the exit from self-renewal using haploid embryonic stem cells.

Cell stem cell - 6 Mar 2014

Leeb Martin, Dietmann Sabine, Paramor Maike, Niwa Hitoshi, Smith Austin

Abstract excerpt

Self-renewal circuitry in embryonic stem cells (ESCs) is increasingly defined. How the robust pluripotency program is dissolved to enable fate transition is less appreciated. Here we develop a forward genetic approach using haploid ESCs. We created libraries of transposon integrations and screened for persistent self-renewal in differentiation-permissive culture. This yielded multiple mutants in the Fgf/Erk and...

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Identifiers

PMID: 24412312
DOI: 10.1016/j.stem.2013.12.008
PMCID: PMC3995090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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