Article

A transcriptional clock of the human pluripotency transition

2025-03-13

Abstract excerpt

<h4>SUMMARY</h4> Developmental timing differs strikingly between mammals. All embryonic and some placental lineages emerge from the pluripotent epiblast in a temporally defined sequence, lasting about two weeks in the human embryo, but only two days in mice. Moreover, the order of lineage segregation and gene expression differ between the species. We used human pluripotent stem cells to recapitulate this window o...

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Literature Corpus work: 4f46c47c-2444-5407-a2e9-41305acff46d
DOI: 10.1101/2025.03.13.643129

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