Article

Efficient Reprogramming of the Epiblast Enables the Generation of Cloned Mice

2026-03-14

Abstract excerpt

Somatic cell nuclear transfer (SCNT) can generate viable mammals despite pervasive epigenetic abnormalities in cloned embryos, yet the mechanism underlying this paradox remains unclear. Here we show, using single-cell transcriptomics, that efficient reprogramming occurs exclusively in the epiblast (EPI), but the not primitive endoderm (PrE) of late mouse SCNT blastocysts. Integrating this with previous findings of...

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Literature Corpus work: af122877-1519-5011-a7f7-313ab7251d87
DOI: 10.64898/2026.03.12.711217

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