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Article

High-throughput fingerprinting of human pluripotent stem cell fate responses and lineage bias.

Nature methods - 1 Dec 2013

Nazareth Emanuel J P, Ostblom Joel E E, Lücker Petra B, Shukla Shreya, Alvarez Manuel M, Oh Steve K W, Yin Ting, Zandstra Peter W

Abstract excerpt

Populations of cells create local environments that lead to emergent heterogeneity. This is particularly evident with human pluripotent stem cells (hPSCs): microenvironmental heterogeneity limits hPSC cell fate control. We developed a high-throughput platform to screen hPSCs in configurable microenvironments in which we optimized colony size, cell density and other parameters to achieve rapid and robust cell fate...

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Identifiers

PMID: 24141495
DOI: 10.1038/nmeth.2684
PMCID: PMC5061564

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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