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Article

Generation and Trapping of a Mesoderm Biased State of Human Pluripotency

2019-10-24

Abstract excerpt

<h4>ABSTRACT</h4> We postulate that exit from pluripotency involves intermediates that retain pluripotency while simultaneously exhibiting lineage-bias. Using a MIXL1 reporter, we explored mesoderm lineage-bias within the human pluripotent stem cell compartment. We identified a substate, which at the single cell level coexpresses pluripotent and mesodermal gene expression programs. Functionally these cells could...

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Identifiers and source

Literature Corpus work
c52ec1b3-4f76-546f-b878-d40952d4b312
DOI
10.1101/813071
Open publication

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