Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.

Abstract excerpt

When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self-renew or commit towards differentiation. Recent findings have provided new insight into the underlying causes of this heterogeneity, which we summarise here...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Regulatory Networks
• Share to Cell Lineage
• Share to Embryonic Stem Cells