Article

Retromer oligomerization drives SNX-BAR coat assembly and membrane constriction

2022-07-29

Abstract excerpt

The retromer coat mediates protein exit from endosomes and impacts many signaling pathways, lysosomal biogenesis, and diseases such as Parkinson’s, Alzheimer’s and COVID-19. Retromer complexes (CSC in yeast) form coats by interconnecting sorting nexins (SNX). The dynamics of this process is poorly explored. Here, we analyze the oligomerization of CSC/SNX-BAR retromer coats on oriented synthetic lipid tubules. SNX-...

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Literature Corpus work: 9ac1f39b-d47c-5111-8e6d-20ca8f1bb9e0
DOI: 10.1101/2022.07.27.501715

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