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Article

A mechanism for retromer endosomal coat complex assembly with cargo.

Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014

Harrison Megan S, Hung Chia-Sui, Liu Ting-ting, Christiano Romain, Walther Tobias C, Burd Christopher G

Abstract excerpt

Retromer is an evolutionarily conserved protein complex composed of the VPS26, VPS29, and VPS35 proteins that selects and packages cargo proteins into transport carriers that export cargo from the endosome. The mechanisms by which retromer is recruited to the endosome and captures cargo are unknown. We show that membrane recruitment of retromer is mediated by bivalent recognition of an effector of PI3K, SNX3, and...

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Cross-Linking Reagents
Endosomes
Liposomes
Mass Spectrometry
rab GTP-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

rab7 GTP-Binding Proteins

Vesicular Transport Proteins

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Identifiers

PMID: 24344282
DOI: 10.1073/pnas.1316482111
PMCID: PMC3890810

Genes

VPS35
SNX3
VPS29

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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A mechanism for retromer endosomal coat complex assembly with cargo.PMID 24344282Read ↗

Membrane recruitment of the cargo-selective retromer subcomplex is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5.Semantic proximity Read ↗

Architecture and mechanism of metazoan retromer:SNX3 tubular coat assemblySemantic proximity Read ↗

Mammalian retromer is an adaptable scaffold for cargo sorting from endosomesSemantic proximity Read ↗

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.Semantic proximity Read ↗

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complexSemantic proximity Read ↗

Vps26p, a component of retromer, directs the interactions of Vps35p in endosome-to-Golgi retrieval.Semantic proximity Read ↗

Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.Semantic proximity Read ↗

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibitionSemantic proximity Read ↗

Retromer's Role in Endosomal Trafficking and Impaired Function in Neurodegenerative Diseases.Semantic proximity Read ↗

Identification of a conserved motif required for Vps35p/Vps26p interaction and assembly of the retromer complex.Semantic proximity Read ↗

EHD1 interacts with retromer to stabilize SNX1 tubules and facilitate endosome-to-Golgi retrieval.Semantic proximity Read ↗

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationSemantic proximity Read ↗

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