Article

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibition

2025-02-04

Abstract excerpt

<h4>ABSTRACT</h4> The endosomal-lysosomal network is a hub of organelles that orchestrate the dynamic sorting of hundreds of integral membrane proteins to maintain cellular homeostasis. VPS29 is a central conductor of this network through its assembly into Retromer, Retriever and Commander endosomal sorting complexes, and its role in regulating RAB GTPase activity. Two VPS29 isoforms have been described, VPS29A a...

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Literature Corpus work: ba3165ef-6a11-5a3c-9738-f9dc631c62d9
DOI: 10.1101/2025.02.04.636264

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