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Article

The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics.

Journal of cell science - 1 Nov 2010

Harbour Michael E, Breusegem Sophia Y A, Antrobus Robin, Freeman Caroline, Reid Evan, Seaman Matthew N J

Abstract excerpt

The retromer complex is required for the efficient endosome-to-Golgi retrieval of the CIMPR, sortilin, SORL1, wntless and other physiologically important membrane proteins. Retromer comprises two protein complexes that act together in endosome-to-Golgi retrieval; the cargo-selective complex is a trimer of VPS35, VPS29 and VPS26 that sorts cargo into tubules for retrieval to the Golgi. Tubules are produced by the...

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Source

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Identifiers

PMID: 20923837
DOI: 10.1242/jcs.071472
PMCID: PMC2964111

Genes

SORL1
VPS29
VPS35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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