Article

Cargo-Adaptor Cooperation Programs Retromer Coat Architecture

2026-05-07

Abstract excerpt

Retromer drives endosomal cargo retrieval in combination with sorting nexin (SNX) adaptors, but how adaptor-cargo combinations specify coat architecture remains unclear. We identify sorting nexin 12 (SNX12) as the retromer adaptor required for human papillomavirus 16 (HPV16) infection and show that the viral L2 capsid protein tail directly engages SNX12-retromer complexes to trigger membrane tubulation. The crysta...

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Literature Corpus work: aa65e7ce-df44-5ced-b6c2-ce82d45a6135
DOI: 10.64898/2026.05.05.722683

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