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Article

Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21.

Protein science : a publication of the Protein Society - 1 May 2024

Romano-Moreno Miguel, Astorga-Simón Elsa N, Rojas Adriana L, Hierro Aitor

Abstract excerpt

Endosomal trafficking ensures the proper distribution of lipids and proteins to various cellular compartments, facilitating intracellular communication, nutrient transport, waste disposal, and the maintenance of cell structure. Retromer, a peripheral membrane protein complex, plays an important role in this process by recruiting the associated actin-polymerizing WASH complex to establish distinct sorting domains....

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Endosomes
VPS35 gene
Mutation
Parkinson Disease
Protein Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Vesicular Transport Proteins

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Open in PubMed Open full text

Identifiers

PMID: 38607248
DOI: 10.1002/pro.4980
PMCID: PMC11010949

Genes

VPS29
VPS35

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29, and FAM21.PMID 38607248Read ↗

Retromer-mediated recruitment of the WASH complex involves discrete interactions between VPS35, VPS29 and Fam21Semantic proximity Read ↗

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complexSemantic proximity Read ↗

Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.Semantic proximity Read ↗

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagySemantic proximity Read ↗

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.Semantic proximity Read ↗

Identification of a VPS29 isoform with restricted association to Retriever and Retromer accessory proteins through auto-inhibitionSemantic proximity Read ↗

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein AggregationSemantic proximity Read ↗

An update on cellular and molecular determinants of Parkinson's disease with emphasis on the role of the retromer complex.Semantic proximity Read ↗

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.Semantic proximity Read ↗

VPS35 and retromer dysfunction in Parkinson's disease.Semantic proximity Read ↗

The VPS35 protein and the role of its impairments in mitochondrial dysfunction in Parkinson's disease.Semantic proximity Read ↗

A mechanism for retromer endosomal coat complex assembly with cargo.Semantic proximity Read ↗

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