Article

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27-Retromer complex

2023-08-15

Abstract excerpt

<h4>ABSTRACT</h4> Endosomal membrane trafficking is mediated by specific protein coats and formation of actin-rich membrane domains. The Retromer complex coordinates with sorting nexin (SNX) cargo adaptors including SNX27, and the SNX27–Retromer assembly interacts with the WASH complex which nucleates actin filaments establishing the endosomal reycling domain. Crystal structures, modelling, biochemical and cellul...

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Literature Corpus work: b0a7b2a9-b3bf-5907-afd2-1b41ec5aad3c
DOI: 10.1101/2023.08.15.553351

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