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Article

Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.

Structure (London, England : 1993) - 7 Apr 2020

Kendall Amy K, Xie Boyang, Xu Peng, Wang Jue, Burcham Rodger, Frazier Meredith N, Binshtein Elad, Wei Hui, Graham Todd R, Nakagawa Terunaga, Jackson Lauren P

Abstract excerpt

Metazoan retromer (VPS26/VPS35/VPS29) associates with sorting nexins on endosomal tubules to sort proteins to the trans-Golgi network or plasma membrane. Mechanisms of metazoan retromer assembly remain undefined. We combine single-particle cryoelectron microscopy with biophysical methods to uncover multiple oligomer structures. 2D class averages reveal mammalian heterotrimers; dimers of trimers; tetramers of...

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Source

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Identifiers

PMID: 32027819
DOI: 10.1016/j.str.2020.01.009
PMCID: PMC7145723

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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