Article

Mammalian retromer is an adaptable scaffold for cargo sorting from endosomes

2019-05-15

Abstract excerpt

In metazoans, retromer (VPS26/VPS35/VPS29) associates with sorting nexin (SNX) proteins to form coats on endosomal tubules and sort cargo proteins to the trans -Golgi network (TGN) or plasma membrane. This core complex is highly conserved from yeast to humans, but molecular mechanisms of metazoan retromer assembly remain undefined. Here we combine single particle cryo-electron microscopy with biophysical methods...

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Literature Corpus work: b9287942-4568-58fa-9cc4-b0d54a7d88eb
DOI: 10.1101/639575

Open publication

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