Article

Identification of functional non-coding variants affecting Alzheimer’s disease risk by Massively Parallel Reporter Assay

2026-05-05

Abstract excerpt

The majority of genetic risk variants for late-onset Alzheimer’s disease (LOAD) reside within non-coding genomic regions, suggesting they exert pathogenic effects by disrupting transcriptional regulatory programs. To systematically identify functional variants, we performed an unbiased, high-throughput Massively Parallel Reporter Assay (MPRA) in the THP-1 human monocytic cell line, screening 2,231 SNPs across 24 L...

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Literature Corpus work: 9a8eb44c-9816-586a-8b00-f9b57a96a7b4
DOI: 10.64898/2026.04.30.721912

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