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Article

Genome-wide discovery of multiple sclerosis genetic risk variant allelic regulatory activity.

G3 (Bethesda, Md.) - 12 Nov 2025

Granitto Marissa, Parks Lois, Shook Molly S, Forney Carmy, Chen Xiaoting, Edsall Lee E, Donmez Omer A, Parameswaran Sreeja, Fisher Kristen S, Zabeti Aram, Lawson Lucinda P, Weirauch Matthew T, Kottyan Leah C

Abstract excerpt

Multiple sclerosis is an immune-mediated demyelinating disease of the central nervous system with a complex etiology involving environmental and genetic factors. Numerous genetic risk loci for multiple sclerosis have been nominated through genome-wide association studies, with most associated variants residing in noncoding regions. However, further work is needed to understand how genetic variation contributes to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40838804
DOI: 10.1093/g3journal/jkaf192
PMCID: PMC12608076

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