Article

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature

2015-01-10

Abstract excerpt

Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs), have facilitated studies that contributed to our understanding of genetic influence on human traits. However, the degree to which cell lines faithfully maintain differences in donor-specific phenotypes is still debated. We have previously reported that standard cell line maintenance practice results in a loss of donor-specific gene expres...

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Literature Corpus work: 9a56b2ca-17dd-5369-ae31-4baf79b2050e
DOI: 10.1101/013631

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