Article

Adding iPSC donor lines does not adequately control for genetic heterogeneity

2026-04-26

Abstract excerpt

Human induced pluripotent stem cell (iPSC)-based disease modelling studies are widely expected to include three to five independent donor lines to control for the contribution of donor genetic background to phenotypic variance. This convention has been formalized into major guidelines, yet no power analysis has evaluated whether these sample sizes can detect, estimate, or control for donor-level genetic effects. H...

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Literature Corpus work: da8da18b-65a6-5fac-b8b5-3e0bc48c750a
DOI: 10.64898/2026.04.22.720258

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