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Article

Cell culture-induced aberrant methylation of the imprinted IG DMR in human lymphoblastoid cell lines.

Epigenetics - 1 Jan 2010

Saferali Aabida, Grundberg Elin, Berlivet Soizik, Beauchemin Hugues, Morcos Lisanne, Polychronakos Constantin, Pastinen Tomi, Graham Jinko, McNeney Brad, Naumova Anna K

Abstract excerpt

DNA methylation patterns are often poorly conserved through cell culturing. To determine the effect of cell immortalization and culture on DNA methylation profiles, we analyzed methylation in the differentially methylated regions (DMR) of five imprinted domains: the intergenic (IG) DMR on chromosome 14q32; potassium voltage-gated channel, KQT-like subfamily, member 1, (KCNQ1); small nuclear ribonucleoprotein...

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Share to Cell Culture Techniques
Share to Chromosomes, Human, Pair 14

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Expression Profiling

Share to Gene Silencing

Share to Genomic Imprinting

Share to Lymphocytes

Source

Identifiers

PMID: 20026906
DOI: 10.4161/epi.5.1.10436

Genes

KCNQ1
MEST
SNRPN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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