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Article

Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential.

Stem cell reports - 9 Feb 2016

Kyttälä Aija, Moraghebi Roksana, Valensisi Cristina, Kettunen Johannes, Andrus Colin, Pasumarthy Kalyan Kumar, Nakanishi Mahito, Nishimura Ken, Ohtaka Manami, Weltner Jere, Van Handel Ben, Parkkonen Olavi, Sinisalo Juha, Jalanko Anu, Hawkins R David, Woods Niels-Bjarne, Otonkoski Timo, Trokovic Ras

Abstract excerpt

Reports on the retention of somatic cell memory in induced pluripotent stem cells (iPSCs) have complicated the selection of the optimal cell type for the generation of iPSC biobanks. To address this issue we compared transcriptomic, epigenetic, and differentiation propensities of genetically matched human iPSCs derived from fibroblasts and blood, two tissues of the most practical relevance for biobanking. Our...

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Identifiers

PMID: 26777058
DOI: 10.1016/j.stemcr.2015.12.009
PMCID: PMC4750096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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