Article

Genetic Variation, Not Cell Type of Origin, Underlies Regulatory Differences in iPSCs

2015-01-19

Abstract excerpt

The advent of induced pluripotent stem cells (iPSCs) 1 revolutionized Human Genetics by allowing us to generate pluripotent cells from easily accessible somatic tissues. This technology can have immense implications for regenerative medicine, but iPSCs also represent a paradigm shift in the study of complex human phenotypes, including gene regulation and disease 2-5 . Yet, an unresolved caveat of the iPSC model...

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Literature Corpus work: 1e192556-6ad4-5600-a7d3-95ca0ea67766
DOI: 10.1101/013888

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