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Article

A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.

PLoS genetics - 1 Nov 2009

Lee Je-Hyuk, Park In-Hyun, Gao Yuan, Li Jin Billy, Li Zhe, Daley George Q, Zhang Kun, Church George M

Abstract excerpt

Normal variation in gene expression due to regulatory polymorphisms is often masked by biological and experimental noise. In addition, some regulatory polymorphisms may become apparent only in specific tissues. We derived human induced pluripotent stem (iPS) cells from adult skin primary fibroblasts and attempted to detect tissue-specific cis-regulatory variants using in vitro cell differentiation. We used...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19911041
DOI: 10.1371/journal.pgen.1000718
PMCID: PMC2766639

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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