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Article

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature.

PLoS genetics - 1 May 2015

Thomas Samantha M, Kagan Courtney, Pavlovic Bryan J, Burnett Jonathan, Patterson Kristen, Pritchard Jonathan K, Gilad Yoav

Abstract excerpt

Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs), have facilitated studies that contributed to our understanding of genetic influence on human traits. However, the degree to which cell lines faithfully maintain differences in donor-specific phenotypes is still debated. We have previously reported that standard cell line maintenance practice results in a loss of donor-specific gene...

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Identifiers

PMID: 25950834
DOI: 10.1371/journal.pgen.1005216
PMCID: PMC4423863

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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