Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature.

PLoS genetics - 1 May 2015

Thomas Samantha M, Kagan Courtney, Pavlovic Bryan J, Burnett Jonathan, Patterson Kristen, Pritchard Jonathan K, Gilad Yoav

Abstract excerpt

Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs), have facilitated studies that contributed to our understanding of genetic influence on human traits. However, the degree to which cell lines faithfully maintain differences in donor-specific phenotypes is still debated. W...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Cell Differentiation
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Herpesvirus 4, Human

Share to Induced Pluripotent Stem Cells

Share to Reproducibility of Results

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 25950834
DOI: 10.1371/journal.pgen.1005216
PMCID: PMC4423863

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25950834-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature.PMID 25950834Read ↗

Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression SignatureSemantic proximity Read ↗

Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cellsSemantic proximity Read ↗

A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.Semantic proximity Read ↗

Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs.Semantic proximity Read ↗

Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential.Semantic proximity Read ↗

Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.Semantic proximity Read ↗

Genetic Variation, Not Cell Type of Origin, Underlies Regulatory Differences in iPSCsSemantic proximity Read ↗

Adding iPSC donor lines does not adequately control for genetic heterogeneitySemantic proximity Read ↗

Genome-wide assessment of imprinted expression in human cells.Semantic proximity Read ↗

The effect of freeze-thaw cycles on gene expression levels in lymphoblastoid cell lines.Semantic proximity Read ↗

Population-scale proteome variation in human induced pluripotent stem cellsSemantic proximity Read ↗

Variability in the generation of induced pluripotent stem cells: importance for disease modeling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.