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Article

Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.

Cell stem cell - 3 Sept 2020

Ortmann Daniel, Brown Stephanie, Czechanski Anne, Aydin Selcan, Muraro Daniele, Huang Yuanhua, Tomaz Rute A, Osnato Anna, Canu Giovanni, Wesley Brandon T, Skelly Daniel A, Stegle Oliver, Choi Ted, Churchill Gary A, Baker Christopher L, Rugg-Gunn Peter J, Munger Steven C, Reinholdt Laura G, Vallier Ludovic

Abstract excerpt

Variability among pluripotent stem cell (PSC) lines is a prevailing issue that hampers not only experimental reproducibility but also large-scale applications and personalized cell-based therapy. This variability could result from epigenetic and genetic factors that influence stem cell behavior. Naive culture conditions minimize epigenetic fluctuation, potentially overcoming differences in PSC line...

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Identifiers

PMID: 32795399
DOI: 10.1016/j.stem.2020.07.019
PMCID: PMC7487768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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