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Article

Genetic Variation, Not Cell Type of Origin, Underlies the Majority of Identifiable Regulatory Differences in iPSCs.

PLoS genetics - 1 Jan 2016

Burrows Courtney K, Banovich Nicholas E, Pavlovic Bryan J, Patterson Kristen, Gallego Romero Irene, Pritchard Jonathan K, Gilad Yoav

Abstract excerpt

The advent of induced pluripotent stem cells (iPSCs) revolutionized human genetics by allowing us to generate pluripotent cells from easily accessible somatic tissues. This technology can have immense implications for regenerative medicine, but iPSCs also represent a paradigm shift in the study of complex human phenotypes, including gene regulation and disease. Yet, an unresolved caveat of the iPSC model system...

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Identifiers

PMID: 26812582
DOI: 10.1371/journal.pgen.1005793
PMCID: PMC4727884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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