Article

A naturally arising broad and potent CD4-binding site antibody with low somatic mutation

2022-03-18

Abstract excerpt

The induction of broadly neutralizing antibodies (bNAbs) is a potential strategy for a vaccine against HIV-1. However, most bNAbs exhibit features such as unusually high somatic hypermutation, including insertions and deletions, which make their induction challenging. VRC01-class bNAbs exhibit extraordinary breadth and potency, but also rank among the most highly somatically-mutated bNAbs. Here we describe a VRC01...

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Literature Corpus work: 1fad50c0-b328-5ec0-a8de-bcbba0d8f559
DOI: 10.1101/2022.03.16.484662

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