Article
Minimally Mutated HIV-1 Broadly Neutralizing Antibodies to Guide Reductionist Vaccine Design.
PLoS pathogens - 1 Aug 2016
Jardine Joseph G, Sok Devin, Julien Jean-Philippe, Briney Bryan, Sarkar Anita, Liang Chi-Hui, Scherer Erin A, Henry Dunand Carole J, Adachi Yumiko, Diwanji Devan, Hsueh Jessica, Jones Meaghan, Kalyuzhniy Oleksandr, Kubitz Michael, Spencer Skye, Pauthner Matthias, Saye-Francisco Karen L, Sesterhenn Fabian, Wilson Patrick C, Galloway Denise M, Stanfield Robyn L, Wilson Ian A, Burton Dennis R, Schief William R
Abstract excerpt
An optimal HIV vaccine should induce broadly neutralizing antibodies (bnAbs) that neutralize diverse viral strains and subtypes. However, potent bnAbs develop in only a small fraction of HIV-infected individuals, all contain rare features such as extensive mutation, insertions, deletions, and/or long complementarity-determining regions, and some are polyreactive, casting doubt on whether bnAbs to HIV can be...
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