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Article

Functional Relevance of Improbable Antibody Mutations for HIV Broadly Neutralizing Antibody Development.

Cell host & microbe - 13 Jun 2018

Wiehe Kevin, Bradley Todd, Meyerhoff R Ryan, Hart Connor, Williams Wilton B, Easterhoff David, Faison William J, Kepler Thomas B, Saunders Kevin O, Alam S Munir, Bonsignori Mattia, Haynes Barton F

Abstract excerpt

HIV-1 broadly neutralizing antibodies (bnAbs) require high levels of activation-induced cytidine deaminase (AID)-catalyzed somatic mutations for optimal neutralization potency. Probable mutations occur at sites of frequent AID activity, while improbable mutations occur where AID activity is infrequent. One bottleneck for induction of bnAbs is the evolution of viral envelopes (Envs) that can select bnAb...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29861171
DOI: 10.1016/j.chom.2018.04.018
PMCID: PMC6002614

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BCR

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