Article

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodies

2025-12-10

Abstract excerpt

<h4>Summary</h4> Elucidating the mechanisms by which broadly neutralizing antibodies (bnAbs) develop to confer durable immunity in humans is pivotal for the rational design of next-generation vaccines and therapeutics. VH3-53/3-66-encoded public antibodies are widely elicited in the population after the COVID-19 pandemic. Here, we isolated 15 VH3-53/3-66-encoded bnAbs from elite neutralizers who experienced seque...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 268a1757-646b-5ecc-9ed7-02128215d6b3
DOI: 10.64898/2025.12.10.693372

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodiesDOI 10.64898/2025.12.10.693372Read

Somatic evolution of a cross-reactive germline antibody that expands its breadth to neutralize new SARS-CoV-2 variantsSemantic proximity Read

Structural determinants of IGHV1-69 public antibodies conferring resilience to SARS-CoV-2 antigenic escapeSemantic proximity Read

The prominent role of a CDR1 somatic hypermutation for convergent IGHV3-53/3-66 antibodies in binding to SARS-CoV-2Semantic proximity Read

Dissecting the impact of somatic hypermutation on SARS-CoV-2 neutralization and viral escapeSemantic proximity Read

Optimizing the breadth of SARS-CoV-2-neutralizing antibodies in vivo and in silicoSemantic proximity Read

Convergent IGHV3-53/3-66 antibodies elicited by Omicron BA.1 infection broadly neutralize emerging SARS-CoV-2 variantsSemantic proximity Read

B cell maturation restored ancestral germlines to control Omicron BA.2.86Semantic proximity Read

Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine designSemantic proximity Read

A potent pan-sarbecovirus neutralizing antibody resilient to epitope diversificationSemantic proximity Read

Fortuitous Somatic Mutations during Antibody Evolution Endow Broad Neutralization against SARS-CoV-2 Omicron VariantsSemantic proximity Read

SARS-CoV-2 breakthrough infections induce somatically hypermutated broadly neutralizing antibodies against heterologous variantsSemantic proximity Read

Vulnerability in the breadth evolution of an influenza broadly neutralizing antibodySemantic proximity Read